Raina is a physician executive and serves as the vice president and chief transformation officer for Penn Medicine. She is also a tenured professor of Emergency Medicine at the University of Pennsylvania and has secondary appointments in the Department of Internal Medicine, Department of Anesthesia and Critical Care, and Division of Health Policy. 

Much of her research and operations work bridges new technologies in the fields of cardiovascular health, mental health, cancer care, disaster medicine, public health, health equity, and resuscitation science. Raina has been continuously funded by the National Institutes of Health since 2011, and her work has been published in journals such as the New England Journal of Medicine, the Journal of the American Medical Association (JAMA), Circulation, and Health Affairs. She is a member of the editorial board of JAMA.  

Raina is an Aspen Health Innovators fellow and was recognized by the Robert Wood Johnson Foundation as one of 10 investigators likely to have a significant impact on the future of health and health care in the United States. She is a member of the National Academy of Medicine.